Author/Presenter: Varun Modi, V1; Qasim, A1; Resident, University of Texas Medical Branch, Pediatrics
Contributing Authors/Faculty Mentors: Aly, Ashraf M1,2;
Jain, Sunil K1,3.
1University of Texas Medical Branch, Department of Pediatrics,
2Division of Pediatric Cardiology,
3Division of Neonatology
POSTER ABSTRACT (View Poster PDF)
Background:
Echocardiography is used for the diagnosis and management of hemodynamically significant patent ductus arteriosus (hsPDA) and pulmonary hypertension (PH) in preterm infants (PI). Highly sensitive Troponin T (hsTnT) is a biomarker of myocardial ischemia. However, little is known about the baseline levels of these biomarkers in PI.
Objective:
To determine the normal range of NTproBNP and hsTnT levels in PI in the first 5 days of life.
Methods:
After IRB approval and parental consent, PI (<34 weeks and < 1500gm) were prospectively enrolled in the observational study. Infants with major congenital or chromosomal anomalies were excluded. On day 3 to 5, an ECHO was performed and blood sample was drawn within 30 minutes of ECHO. Serum was collected by centrifuging blood and saved at -800C. Infants were divided into 3 groups based on ECHO results PDA diameter): No PDA, PDA < 1.5 mm and hsPDA > 1.5 mm diameter. Clinical, demographic, ECHO and biochemical markers data was collected and analyzed using chi-square and ANOVA tests.
Results:
We recruited 76 PI (No PDa n=44, hsPDA n=20) with mean gestation 26 to 28 weeks and birth weight 884 -1056 grams. Table 2 shows demographic data of all infants. NTproBNP and hsTnT were significantly lower in infants with no PDA. Table 1 compares the mean values of these biochemical markers between those with no PDA, non-significant PDA and significant PDA. Additionally, Fig 1 shows the mean, upper and lower quartiles for hsTnT and NTproBNP levels in the 3 groups, respectively.
Conclusion:
Normal hsTnT and NTproBNP levels in PI within 5 days of life are 158 74 pg/mL and 2051 1242 ng/L respectively. hsPDA increases both hsTnT and NTproBNP in PI.